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Alexander Spirin was an eminent Russian biochemist, who was one of the early pioneers in ribosome research. His lifelong research interests were nucleic acids and protein synthesis.

Among his many early achievements he predicted the existence of messenger RNA, and showed that the RNA content of ribosomes does not code for protein, but is structural in nature. As someone coming into the field rather late, as a structural biologist, I mostly appreciated his work on mRNA-tRNA translocation. He had deep insights Read More Just accepted by Proteomics Posted by: Joachim Frank Tags: Posted date: October 7, No comment October 7, A time-resolved cryo-EM Study of S.

cerevisiae 80S Ribosome Protein Composition in Response to a Change in Carbon Source, dating seite flirtschiff. Ming Sun, Bingxin Shen, Wen Li, Parimal Samir, Christopher M Browne, Andrew Link and Joachim Frank ABSTRACT The role of the ribosome in the regulation of gene expression has come into increased focus.

It has been proposed that ribosomes are catalytic engines capable of changing their protein composition in response to environmental stimuli. We employed time-resolved cryo-electron microscopy Read More GABA Receptor Paper in NATURE — example of a successful technology transfer Posted by: Joachim Frank Tags: Posted date: August 12, No comment August 12, Structure of human GABA B receptor in an inactive state.

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Slesinger, Matthias Quick, Joseph Graziano, Hongtao Yu, Oliver Fiehn, Oliver B. Structure of human GABA B receptor in an inactive state. Slesinger, Matthias Quick, Read More A Brief Guide to Three Papers from Our Group Related to Structural Heterogeneity Posted by: Joachim Frank Tags: Posted date: April 3, dating seite flirtschiff, No comment April 3, Structural heterogeneity has been long recognized as a problem for structure research by cryo-EM.

Different molecule species, or molecules in different conformational states or binding configurations may co-exist. Without resolving this heterogeneity, reconstructions are blurred, and are invalid as representations of any one physical structure. Dating seite flirtschiff, widely used approaches to dating seite flirtschiff heterogeneity, such as Relion, are based on the assumption that the structure exists in a few discrete conformations.

Beginning with a paper we published jointly with dating seite flirtschiff group of Abbas Ourmazd at the University Read More The Indian Statistical Institute in Calcutta Posted by: Joachim Frank Tags: Posted date: January 24, Comment January 24, dating seite flirtschiff, Read More The Electron Microscope — from a Sketch in to Reality Posted by: Joachim Frank Dating seite flirtschiff Posted date: December 26, No comment December 26, A sketch circulated by Pablo Guerra Lahoz on Twitter prompted me to put together this brief chronicle of the invention that has changed our lives in so many ways.

in He went to the Technical University of Berlin in where he finished his Ph. He hypothesized that electrons with their much smaller wavelength could be used to image objects with much higher resolution than light microscopes.

The sketch dated March 9, dating seite flirtschiff, is a testimony of brilliance. Read More Hirschegg — old memories from the s. Posted by: Joachim Frank Tags: Posted date: October 11, No comment October 11, I was recently invited by Michael Roehrl to present a talk at the Memorial Sloan Kettering Institute, here on the East Side of Manhattan.

Bacterial translation initiation entails the tightly regulated joining of the 50S ribosomal subunit to an initiator transfer RNA fMet-tRNAfMet -containing 30S ribosomal initiation complex IC to form a 70S IC that subsequently matures into a 70S elongation-competent complex 70S EC.

Rapid and accurate 70S IC formation Read More Sydney Brenner — Posted by: Joachim Frank Tags: Posted date: April 6, No comment April 6, Sydney Brenner died on April 5 in Singapore at the age of Brenner has been called a giant of molecular biology.

Among his many contributions to this field are key experiments in proving that the mRNA is the carrier of genetic information, and the substrate for protein synthesis on the ribosome. Here I Read More Next Page ».

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